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phnL methylphosphonate degradation complex subunit PhnL [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948612, updated on 2-May-2024

Summary

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Gene symbol
phnL
Gene description
methylphosphonate degradation complex subunit PhnL
Primary source
ASAP:ABE-0013421
Locus tag
b4096
See related
ECOCYC:EG10721
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4089
Summary
Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10721]. phnL is a member of the 14-gene phnCDEFGHIJKLMNOP operon which is involved in phosphonate uptake and metabolism and is a member of the phosphate regulon . [More information is available at EcoCyc: EG10721].
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Genomic context

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Sequence:
NC_000913.3 (4317215..4317895, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase Neighboring gene aminoalkylphosphonate N-acetyltransferase Neighboring gene ribose 1,5-bisphosphate phosphokinase Neighboring gene RPnTP hydrolase Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnI Neighboring gene carbon-phosphorus lyase core complex subunit PhnH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway. Jochimsen B, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21705661, Free PMC Article
  2. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva GM, et al. Appl Microbiol Biotechnol, 1998 May. PMID 9650256
  3. Intermediates in the transformation of phosphonates to phosphate by bacteria. Kamat SS, et al. Nature, 2011 Nov 16. PMID 22089136, Free PMC Article
  4. Genes for phosphonate biodegradation in Escherichia coli. Wanner BL. SAAS Bull Biochem Biotechnol, 1992 Jan. PMID 1368181
  5. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Metcalf WW, et al. J Bacteriol, 1991 Jan. PMID 1846145, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within organic phosphonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic phosphonate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic phosphonate transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of carbon phosphorus lyase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
methylphosphonate degradation complex subunit PhnL
NP_418520.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4317215..4317895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418520.1 methylphosphonate degradation complex subunit PhnL [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418520.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L9HUP8
    Conserved Domains (1) summary
    COG4778
    Location:1 → 226
    PhnL; Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism]
Nucleotide Protein
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