dcuA C4-dicarboxylate transporter DcuA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: dcuA
Gene description: C4-dicarboxylate transporter DcuA
Primary source: ASAP:ABE-0013546
Locus tag: b4138
See related: ECOCYC:EG11225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4132; genA
Summary: IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11225]. The DcuA transporter is one of three transporters known to be responsible for the uptake of C4-dicarboxylates such as fumarate under anaerobic conditions. [More information is available at EcoCyc: EG11225].
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NC_000913.3 Genomic Context describing neighboring genes

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Influence of C4 -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
Title: Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
In this work, it is shown that DcuA is required for aerobic growth with L-aspartate as a nitrogen source.
Title: DcuA of aerobically grown Escherichia coli serves as a nitrogen shuttle (L-aspartate/fumarate) for nitrogen uptake.

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Function	Evidence Code	Pubs
enables C4-dicarboxylate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables C4-dicarboxylate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables succinate:fumarate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within C4-dicarboxylate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in C4-dicarboxylate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-aspartate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular nitrogen compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fumarate transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

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