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frdB fumarate reductase iron-sulfur protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948666, updated on 4-Feb-2024

Summary

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Gene symbol
frdB
Gene description
fumarate reductase iron-sulfur protein
Primary source
ASAP:ABE-0013602
Locus tag
b4153
See related
ECOCYC:EG10331
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4149
Summary
HT_Cmplx15_Mem: [More information is available at EcoGene: EG10331]. This is one of two catalytic subunits of the four subunit enzyme. [More information is available at EcoCyc: EG10331].
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Genomic context

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Sequence:
NC_000913.3 (4379783..4380517, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarate reductase membrane protein FrdD Neighboring gene fumarate reductase membrane protein FrdC Neighboring gene fumarate reductase flavoprotein subunit Neighboring gene EF-P-lysine lysyltransferase Neighboring gene putative transporter YjeM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of cysteine to serine mutations on the properties of the [4Fe-4S] center in Escherichia coli fumarate reductase. Kowal AT, et al. Biochemistry, 1995 Sep 26. PMID 7547971
  2. Detection of a tetranuclear iron-sulfur center in fumarate reductase from Escherichia coli by electron paramagnetic resonance spectroscopy. Johnson MK, et al. Biochem Biophys Res Commun, 1985 Sep 16. PMID 2996525
  3. In vivo detection of a three iron cluster in fumarate reductase from Escherichia coli. Johnson MK, et al. Biochem Biophys Res Commun, 1985 Sep 16. PMID 2996520
  4. Site-directed mutagenesis of conserved cysteine residues in Escherichia coli fumarate reductase: modification of the spectroscopic and electrochemical properties of the [2Fe-2S] cluster. Werth MT, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2174169, Free PMC Article
  5. [3Fe-4S] to [4Fe-4S] cluster conversion in Escherichia coli fumarate reductase by site-directed mutagenesis. Manodori A, et al. Biochemistry, 1992 Mar 17. PMID 1312345

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Location and nucleotide sequence of frdB, the gene coding for the iron-sulphur protein subunit of the fumarate reductase of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 3 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within anaerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bacterial-type flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fermentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane fumarate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane fumarate reductase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane fumarate reductase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
fumarate reductase iron-sulfur protein
NP_418577.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4379783..4380517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418577.1 fumarate reductase iron-sulfur protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418577.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826TKU6
    Conserved Domains (1) summary
    PRK12385
    Location:1 → 244
    PRK12385; succinate dehydrogenase/fumarate reductase iron-sulfur subunit
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials