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cycA D-serine/alanine/glycine/:H(+)symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948725, updated on 11-Apr-2024

Summary

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Gene symbol
cycA
Gene description
D-serine/alanine/glycine/:H(+)symporter
Primary source
ASAP:ABE-0013764
Locus tag
b4208
See related
ECOCYC:EG12504
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dagA; ECK4204; ytfD
Summary
CycA is a transporter involved in the uptake of glycine, serine and alanine. [More information is available at EcoCyc: EG12504].
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Genomic context

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Sequence:
NC_000913.3 (4429864..4431276)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene cell division protein YtfB Neighboring gene peptidyl-prolyl cis-trans isomerase FklB Neighboring gene iron-sulfur cluster repair protein YtfE Neighboring gene inner membrane protein YtfF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli. Shi H, et al. Microbiol Spectr, 2022 Dec 21. PMID 36377953, Free PMC Article
  2. Characterization of cycA mutants of Escherichia coli. An assay for measuring in vivo mutation rates. Fehér T, et al. Mutat Res, 2006 Mar 20. PMID 16376388
  3. Identification and characterization of the main beta-alanine uptake system in Escherichia coli. Schneider F, et al. Appl Microbiol Biotechnol, 2004 Oct. PMID 15221223
  4. Mechanism of D-cycloserine action: transport mutants for D-alanine, D-cycloserine, and glycine. Wargel RJ, et al. J Bacteriol, 1971 Mar. PMID 4926674, Free PMC Article
  5. Transport systems for alanine, serine, and glycine in Escherichia coli K-12. Robbins JC, et al. J Bacteriol, 1973 Oct. PMID 4583203, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
    Title: CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
  2. beta-Alanine uptake was found to be an active process catalyzed by the amino acid carrier CycA.
    Title: Identification and characterization of the main beta-alanine uptake system in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-alanine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables D-serine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-alanine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-alanine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-alanine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within D-serine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within L-alanine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within beta-alanine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
D-serine/alanine/glycine/:H(+)symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4429864..4431276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418629.1 D-serine/alanine/glycine/:H(+)symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418629.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3P5DKG1
    Conserved Domains (1) summary
    PRK11049
    Location:2 → 470
    PRK11049; D-alanine/D-serine/glycine permease; Provisional
Nucleotide Protein
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