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argI ornithine carbamoyltransferase ArgI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948774, updated on 2-May-2024

Summary

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Gene symbol
argI
Gene description
ornithine carbamoyltransferase ArgI
Primary source
ASAP:ABE-0013927
Locus tag
b4254
See related
ECOCYC:EG10069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4247
Summary
argI and argF have same enzyme activity. [More information is available at EcoGene: EG10069]. In the test tube, not in the cell, a family of four isoenzymes forms by assortment of two closely similar polypeptides, the chain F-monomer and chain I-monomer, to give active trimers FFF, FFI, FII, and III. [More information is available at EcoCyc: EG10069].
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Genomic context

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Sequence:
NC_000913.3 (4477307..4478311, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF386 domain-containing toxin-antitoxin biofilm protein TabA Neighboring gene protein YjgL Neighboring gene ribonuclease E inhibitor protein B Neighboring gene putative N-acetyltransferase YjgM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arm-domain interactions in proteins: a review. Schleif R. Proteins, 1999 Jan 1. PMID 10336376
  2. The DNA sequence of argI from Escherichia coli K12. Bencini DA, et al. Nucleic Acids Res, 1983 Dec 10. PMID 6369246, Free PMC Article
  3. Substrate specificity and protonation state of ornithine transcarbamoylase as determined by pH studies. Kuo LC, et al. Biochemistry, 1985 Aug 27. PMID 3907689
  4. Isolation of Escherichia coli mutants with changed regulation of uracil uptake. Fast R. J Bacteriol, 1978 Dec. PMID 363695, Free PMC Article
  5. Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. Langley DB, et al. J Biol Chem, 2000 Jun 30. PMID 10747936

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ornithine carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine carbamoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ornithine carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine biosynthetic process via ornithine NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in citrulline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in citrulline biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ornithine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ornithine carbamoyltransferase ArgI
NP_418675.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4477307..4478311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418675.1 ornithine carbamoyltransferase ArgI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418675.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7H9QRS9
    Conserved Domains (1) summary
    PRK03515
    Location:1 → 334
    PRK03515; ornithine carbamoyltransferase subunit I; Provisional
Nucleotide Protein
Heading Accession and Version

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