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fadI 3-ketoacyl-CoA thiolase FadI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948823, updated on 4-Apr-2024

Summary

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Gene symbol
fadI
Gene description
3-ketoacyl-CoA thiolase FadI
Primary source
ASAP:ABE-0007725
Locus tag
b2342
See related
ECOCYC:G7213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2336; yfcY
Summary
Also known as beta-oxidation complex II. [More information is available at EcoGene: EG14128]. During anaerobic beta-oxidation of fatty acids FadI, FadJ, and FadK serve functions parallel to those of FadA, FadB, and FadD in the aerobic pathway . [More information is available at EcoCyc: G7213].
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Genomic context

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Sequence:
NC_000913.3 (2459159..2460469, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YfcV Neighboring gene phosphohistidine phosphatase SixA Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. Zhang YM, et al. J Biol Chem, 2002 May 3. PMID 11859088
  2. YfcX enables medium-chain-length poly(3-hydroxyalkanoate) formation from fatty acids in recombinant Escherichia coli fadB strains. Snell KD, et al. J Bacteriol, 2002 Oct. PMID 12270828, Free PMC Article
  3. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites. Qin ZS, et al. Nat Biotechnol, 2003 Apr. PMID 12627170
  4. Factors influencing the identification of transcription factor binding sites by cross-species comparison. McCue LA, et al. Genome Res, 2002 Oct. PMID 12368244, Free PMC Article
  5. A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. Campbell JW, et al. Mol Microbiol, 2003 Feb. PMID 12535077

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation, unsaturated, even number IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-ketoacyl-CoA thiolase FadI
NP_416844.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2459159..2460469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416844.1 3-ketoacyl-CoA thiolase FadI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416844.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y1N5
    Conserved Domains (1) summary
    PRK08963
    Location:9 → 436
    fadI; 3-ketoacyl-CoA thiolase; Reviewed
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials