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nadC quinolinate phosphoribosyltransferase (decarboxylating) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948869, updated on 23-Nov-2023

Summary

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Gene symbol
nadC
Gene description
quinolinate phosphoribosyltransferase (decarboxylating)
Primary source
ASAP:ABE-0000374
Locus tag
b0109
See related
ECOCYC:EG11546
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0108
Summary
Quinolinate phosphoribosyltransferase (NadC) catalyzes the third step in the de novo biosynthesis of NAD from L-aspartate . nadC mutants excrete quinolinate . [More information is available at EcoCyc: EG11546].
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Genomic context

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Sequence:
NC_000913.3 (117752..118645, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein HofC Neighboring gene T2SSE family protein Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD Neighboring gene 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lys70 of E. coli quinolinate phosphoribosyltransferase is protected from chemical modification by formation of an inhibitor complex. Gaur R, et al. Protein Pept Lett, 2006. PMID 16472078
  2. The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli. Bhatia R, et al. Arch Biochem Biophys, 1996 Jan 15. PMID 8561507
  3. De novo biosynthesis of nicotinamide adenine dinucleotide in Escherichia coli: excretion of quinolinic acid by mutants lacking quinolinate phosphoribosyl transferase. Chandler JL, et al. J Bacteriol, 1972 Jul. PMID 4360223, Free PMC Article
  4. Chromosomal location of the C gene involved in the biosynthesis of nicotinamide adenine dinucleotide in Escherichia coli K-12. Tritz GJ, et al. J Bacteriol, 1970 Oct. PMID 4319723, Free PMC Article
  5. Quinolinate phosphoribosyl transferase is not the oxygen-sensitive site of nicotinamide adenine dinucleotide biosynthesis. Gardner PR, et al. Free Radic Biol Med, 1990. PMID 2139630

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' NAD biosynthetic process from aspartate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
quinolinate phosphoribosyltransferase (decarboxylating)
NP_414651.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    117752..118645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414651.1 quinolinate phosphoribosyltransferase (decarboxylating) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414651.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9VQB6
    Conserved Domains (1) summary
    PRK09016
    Location:1 → 297
    PRK09016; carboxylating nicotinate-nucleotide diphosphorylase
Nucleotide Protein
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