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yjjX inosine/xanthosine triphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948919, updated on 23-Nov-2023

Summary

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Gene symbol
yjjX
Gene description
inosine/xanthosine triphosphatase
Primary source
ASAP:ABE-0014411
Locus tag
b4394
See related
ECOCYC:EG12600
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4386
Summary
ITP and XTP are products of oxidative damage and inhibitors of transcription, but the physiological significance and in vivo substrates for the in vitro triphosphatase activity is uncertain. [More information is available at EcoGene: EG12600]. YjjX is a phosphatase that preferentially hydrolyzes inosine triphosphate (ITP) and xanthosine triphosphate (XTP). [More information is available at EcoCyc: EG12600].
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Genomic context

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Sequence:
NC_000913.3 (4633233..4633745, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene soluble lytic murein transglycosylase Neighboring gene DNA-binding transcriptional repressor TrpR Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob Neighboring gene PF05981 family protein CreA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YjjX: from structure "Tu" function. Rao Z. Structure, 2005 Oct. PMID 16216571
  2. Nucleotide sequence of the Salmonella typhimurium trpR gene. Skrypka I, et al. DNA Seq, 1994. PMID 7841459
  3. Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli. Budke B, et al. Mol Microbiol, 2010 Jan. PMID 19943897, Free PMC Article
  4. DNA sequence of the E. coli trpR gene and prediction of the amino acid sequence of Trp repressor. Singleton CK, et al. Nucleic Acids Res, 1980 Apr 11. PMID 7001368, Free PMC Article
  5. Piecing together the structure-function puzzle: experiences in structure-based functional annotation of hypothetical proteins. Adams MA, et al. Proteomics, 2007 Aug. PMID 17639604

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ITPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thiamine metabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in thiamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inosine/xanthosine triphosphatase
NP_418811.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4633233..4633745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418811.2 inosine/xanthosine triphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418811.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ABS5
    Conserved Domains (1) summary
    PRK05074
    Location:1 → 170
    PRK05074; non-canonical purine NTP phosphatase
Nucleotide Protein
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