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udp uridine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948987, updated on 2-May-2024

Summary

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Gene symbol
udp
Gene description
uridine phosphorylase
Primary source
ASAP:ABE-0012528
Locus tag
b3831
See related
ECOCYC:EG11045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3825
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11045].
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Genomic context

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Sequence:
NC_000913.3 (4016431..4017192)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cobalamin-independent homocysteine transmethylase Neighboring gene putative dienelactone hydrolase Neighboring gene putative recombination limiting protein RmuC Neighboring gene bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP alters protein folding and function of Escherichia coli uridine phosphorylase. Liu YK, et al. Arch Biochem Biophys, 2017 Nov 15. PMID 28917600
  2. Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines. Bu W, et al. Acta Crystallogr D Biol Crystallogr, 2005 Jul. PMID 15983408
  3. Characterization of Escherichia coli uridine phosphorylase by single-site mutagenesis. Oliva I, et al. J Biochem, 2004 Apr. PMID 15115774
  4. [Structural-functional analysis of the promoter region of Escherichia coli udp gene]. Ovcharova IV, et al. Genetika, 2004 Jan. PMID 15027196
  5. Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium. Caradoc-Davies TT, et al. J Mol Biol, 2004 Mar 19. PMID 15003451

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our preliminary findings suggest that ATP can alter the protein folding and function of enzymes via apparent destabilization. This mechanism may be significant for proteins functioning under conditions of high levels of ATP, such as cancer cell environments.
    Title: ATP alters protein folding and function of Escherichia coli uridine phosphorylase.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uridine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uridine phosphorylase
NP_418275.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4016431..4017192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418275.1 uridine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418275.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L5VA71
    Conserved Domains (1) summary
    PRK11178
    Location:4 → 253
    PRK11178; uridine phosphorylase; Provisional
Nucleotide Protein
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