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caiB gamma-butyrobetainyl-CoA:carnitine CoA transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948997, updated on 2-May-2024

Summary

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Gene symbol
caiB
Gene description
gamma-butyrobetainyl-CoA:carnitine CoA transferase
Primary source
ASAP:ABE-0000136
Locus tag
b0038
See related
ECOCYC:EG11559
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0039; yaaN
Summary
Uses gamma-butyrobetainyl-CoA as co-factor. [More information is available at EcoGene: EG11559]. The crystal structure of CaiB has been solved and shows that two monomers form an interlaced dimer . [More information is available at EcoCyc: EG11559].
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Genomic context

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Sequence:
NC_000913.3 (37898..39115, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene crotonobetainyl-CoA hydratase Neighboring gene carnitine--CoA ligase Neighboring gene crotonobetainyl-CoA reductase Neighboring gene L-carnitine:gamma-butyrobetaine antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria. Todd JD, et al. Science, 2007 Feb 2. PMID 17272727
  2. Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA. Rangarajan ES, et al. Biochemistry, 2005 Apr 19. PMID 15823031
  3. Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism. Stenmark P, et al. Biochemistry, 2004 Nov 9. PMID 15518548
  4. Cloning, nucleotide sequence, and expression of the Escherichia coli gene encoding carnitine dehydratase. Eichler K, et al. J Bacteriol, 1994 May. PMID 8188598, Free PMC Article
  5. Purification and properties of carnitine dehydratase from Escherichia coli--a new enzyme of carnitine metabolization. Jung H, et al. Biochim Biophys Acta, 1989 Jun 28. PMID 2663076

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Crotonobetaine reductase from Escherichia coli consists of two proteins.
  2. crystal structure
    Title: Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA.
  3. The binding of coenzyme A to CaiB induces a domain movement that closes the active site of the protein and can play an important role in coupling substrate binding to initiation of the catalytic reaction.
    Title: Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-carnitine CoA-transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables L-carnitine CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring sulphur-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carnitine catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-butyrobetainyl-CoA:carnitine CoA transferase
NP_414580.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    37898..39115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414580.1 gamma-butyrobetainyl-CoA:carnitine CoA transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414580.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ACK0, A0A8S7EC95, A0AA88ELK6
    Conserved Domains (1) summary
    PRK03525
    Location:1 → 405
    PRK03525; L-carnitine CoA-transferase
Nucleotide Protein
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Gene LinkOut

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