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focB formate channel FocB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949032, updated on 11-Apr-2024

Summary

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Gene symbol
focB
Gene description
formate channel FocB
Primary source
ASAP:ABE-0008206
Locus tag
b2492
See related
ECOCYC:G7309
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2488
Summary
FocB is a putative formate transporter, belonging to the FNT family of formate and nitrite transporters . [More information is available at EcoCyc: G7309].
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Genomic context

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Sequence:
NC_000913.3 (2613934..2614782)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 4 catalytic subunit HyfI Neighboring gene putative hydrogenase 4 assembly protein Neighboring gene DNA-binding transcriptional activator HyfR Neighboring gene putative transporter YfgO Neighboring gene beta-barrel assembly-enhancing protease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Hultdin UW, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208176, Free PMC Article
  2. pH and a mixed carbon-substrate spectrum influence FocA- and FocB-dependent, formate-driven H2 production in Escherichia coli. Hakobyan B, et al. FEMS Microbiol Lett, 2018 Nov 1. PMID 30247527
  3. Phylogenetic characterization of novel transport protein families revealed by genome analyses. Saier MH Jr, et al. Biochim Biophys Acta, 1999 Feb 25. PMID 10082980
  4. Structure of FocB--a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Hultdin UW, et al. FEBS J, 2010 Aug. PMID 20646069
  5. Sequences that direct significant levels of frameshifting are frequent in coding regions of Escherichia coli. Gurvich OL, et al. EMBO J, 2003 Nov 3. PMID 14592990, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results suggest that regulation of formate translocation direction by FocA/FocB channels is important for maintaining internal pH and proton motive force by modulating H2 production.
    Title: pH and a mixed carbon-substrate spectrum influence FocA- and FocB-dependent, formate-driven H2 production in Escherichia coli.
  2. To elucidate the detailed function of FocB, they have determined its crystal structure at 1.4 A resolution. FocB is an all alpha-helical protein with a helix-turn-helix motif.
    Title: Structure of FocB--a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli.
  3. FocB was crystallized using the hanging-drop vapour-diffusion method at 295 K. A native data set to 2.0 A resolution was collected at 100 K using synchrotron radiation
    Title: Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables formate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mixed acid fermentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
formate channel FocB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2613934..2614782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416987.1 formate channel FocB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416987.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QC39
    Conserved Domains (1) summary
    PRK09713
    Location:1 → 281
    focB; formate transporter
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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