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mglB D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949041, updated on 11-Apr-2024

Summary

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Gene symbol
mglB
Gene description
D-galactose/methyl-galactoside ABC transporter periplasmic binding protein
Primary source
ASAP:ABE-0007108
Locus tag
b2150
See related
ECOCYC:EG10593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2143
Summary
MglB binds D-galactose and D-glucose and mediates chemotaxis through the Trg chemoreceptor. [More information is available at EcoGene: EG10593]. MglB is the periplasmic binding component of the galactose ABC transporter. [More information is available at EcoCyc: EG10593].
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Genomic context

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Sequence:
NC_000913.3 (2239350..2240348, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit Neighboring gene DNA-binding transcriptional dual regulator GalS Neighboring gene DUF418 domain-containing protein YeiB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-based design of a periplasmic binding protein antagonist that prevents domain closure. Borrok MJ, et al. ACS Chem Biol, 2009 Jun 19. PMID 19348466, Free PMC Article
  2. Engineering of ligand specificity of periplasmic binding protein for glucose sensing. Sakaguchi-Mikami A, et al. Biotechnol Lett, 2008 Aug. PMID 18414800
  3. A strategic fluorescence labeling of D-galactose/D-glucose-binding protein from Escherichia coli helps to shed light on the protein structural stability and dynamics. Scognamiglio V, et al. J Proteome Res, 2007 Nov. PMID 17924684
  4. Engineering and rapid selection of a low-affinity glucose/galactose-binding protein for a glucose biosensor. Amiss TJ, et al. Protein Sci, 2007 Nov. PMID 17905834, Free PMC Article
  5. Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures. Borrok MJ, et al. Protein Sci, 2007 Jun. PMID 17473016, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within methylgalactoside transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-galactose/methyl-galactoside ABC transporter periplasmic binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2239350..2240348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416655.1 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416655.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A7E2, A0A793GD59
    Conserved Domains (1) summary
    PRK15395
    Location:2 → 331
    PRK15395; galactose/glucose ABC transporter substrate-binding protein MglB
Nucleotide Protein
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