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lpxH UDP-2,3-diacylglucosamine diphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949053, updated on 4-Apr-2024

Summary

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Gene symbol
lpxH
Gene description
UDP-2,3-diacylglucosamine diphosphatase
Primary source
ASAP:ABE-0001804
Locus tag
b0524
See related
ECOCYC:EG12666
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0517; ybbF
Summary
UDP-2,3-diacylglucosamine hydrolase (LpxH) catalyzes the fourth step in lipid A synthesis. [More information is available at EcoCyc: EG12666].
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Genomic context

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Sequence:
NC_000913.3 (553218..553940, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2877 domain-containing protein YlbF Neighboring gene putative carbamate kinase Neighboring gene 5-(carboxyamino)imidazole ribonucleotide synthase Neighboring gene N(5)-carboxyaminoimidazole ribonucleotide mutase Neighboring gene peptidyl-prolyl cis-trans isomerase B Neighboring gene cysteine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fatty acyl derivatives of glucosamine 1-phosphate in Escherichia coli and their relation to lipid A. Complete structure of A diacyl GlcN-1-P found in a phosphatidylglycerol-deficient mutant. Takayama K, et al. J Biol Chem, 1983 Jun 25. PMID 6345522
  2. Identification and sequence analysis of Escherichia coli purE and purK genes encoding 5'-phosphoribosyl-5-amino-4-imidazole carboxylase for de novo purine biosynthesis. Watanabe W, et al. J Bacteriol, 1989 Jan. PMID 2644189, Free PMC Article
  3. Biosynthesis, transport, and modification of lipid A. Trent MS. Biochem Cell Biol, 2004 Feb. PMID 15052329
  4. Lipid A modification systems in gram-negative bacteria. Raetz CR, et al. Annu Rev Biochem, 2007. PMID 17362200, Free PMC Article
  5. Lipopolysaccharide endotoxins. Raetz CR, et al. Annu Rev Biochem, 2002. PMID 12045108, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. confirmed biochemically that LpxH is inhibited by a previously identified antibacterial compound, determined the potency of this inhibitor, and modeled its binding mode in the LpxH active site
    Title: The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-2,3-diacylglucosamine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-2,3-diacylglucosamine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-2,3-diacylglucosamine hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-2,3-diacylglucosamine hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-2,3-diacylglucosamine diphosphatase
NP_415057.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    553218..553940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415057.1 UDP-2,3-diacylglucosamine diphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415057.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DXC5
    Conserved Domains (1) summary
    PRK05340
    Location:1 → 240
    PRK05340; UDP-2,3-diacylglucosamine hydrolase; Provisional
Nucleotide Protein
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Gene LinkOut

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