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folM dihydromonapterin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949096, updated on 4-Feb-2024

Summary

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Gene symbol
folM
Gene description
dihydromonapterin reductase
Primary source
ASAP:ABE-0005364
Locus tag
b1606
See related
ECOCYC:G6862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1601; ydgB
Summary
The folM gene encodes a dihydrofolate reductase. [More information is available at EcoCyc: G6862].
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Genomic context

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Sequence:
NC_000913.3 (1680976..1681698)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing protein YdgH Neighboring gene putative arginine:ornithine antiporter Neighboring gene GlpM family protein Neighboring gene DNA-binding transcriptional regulator RstA Neighboring gene sensory histidine kinase RstB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigation of osmolyte effects on FolM: comparison with other dihydrofolate reductases. Bhojane PP, et al. Biochemistry, 2014 Mar 4. PMID 24517487
  2. Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: effects of ligand binding. Yamamoto T, et al. J Biochem, 2004 Jun. PMID 15213241
  3. FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli. Giladi M, et al. J Bacteriol, 2003 Dec. PMID 14617668, Free PMC Article
  4. Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids. Maini R, et al. Biochemistry, 2015 Jun 16. PMID 25982410, Free PMC Article
  5. FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa. Pribat A, et al. J Bacteriol, 2010 Jan. PMID 19897652, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that substrate specificity of peptidyl transferase activity of 23S rRNA allows incorporation of beta-alanine analogs into dihydrofolate reductase (folM) at four sites.
    Title: Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids.
  2. Purified FolM in E. coli showed high, NADPH-dependent dihydromonapterin reductase activity.
    Title: FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dihydrofolate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydromonapterin reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pteridine-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
dihydromonapterin reductase
NP_416123.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1680976..1681698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416123.1 dihydromonapterin reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416123.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EKB0
    Conserved Domains (1) summary
    PRK06483
    Location:5 → 240
    PRK06483; dihydromonapterin reductase; Provisional
Nucleotide Protein
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