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fadJ 3-hydroxyacyl-CoA dehydrogenase FadJ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949097, updated on 4-Apr-2024

Summary

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Gene symbol
fadJ
Gene description
3-hydroxyacyl-CoA dehydrogenase FadJ
Primary source
ASAP:ABE-0007723
Locus tag
b2341
See related
ECOCYC:G7212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2335; yfcX
Summary
Also known as beta-oxidation complex II. [More information is available at EcoGene: EG14127]. During anaerobic beta-oxidation of fatty acids FadI, FadJ, and FadK serve functions parallel to those of FadA, FadB, and FadD in the aerobic pathway . [More information is available at EcoCyc: G7212].
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Genomic context

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Sequence:
NC_000913.3 (2457015..2459159, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YfcV Neighboring gene phosphohistidine phosphatase SixA Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a new enoyl coenzyme A hydratase involved in biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli. Park SJ, et al. J Bacteriol, 2003 Sep. PMID 12949091, Free PMC Article
  2. The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli. Zhang YM, et al. J Biol Chem, 2002 May 3. PMID 11859088
  3. YfcX enables medium-chain-length poly(3-hydroxyalkanoate) formation from fatty acids in recombinant Escherichia coli fadB strains. Snell KD, et al. J Bacteriol, 2002 Oct. PMID 12270828, Free PMC Article
  4. Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression. Beloin C, et al. Mol Microbiol, 2004 Feb. PMID 14731270
  5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxybutyryl-CoA epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxyacyl-CoA dehydrogenase FadJ
NP_416843.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2457015..2459159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416843.1 3-hydroxyacyl-CoA dehydrogenase FadJ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416843.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6A2A6
    Conserved Domains (1) summary
    PRK11154
    Location:1 → 708
    fadJ; fatty acid oxidation complex subunit alpha FadJ
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials