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CD302 CD302 molecule [ Homo sapiens (human) ]

Gene ID: 9936, updated on 5-Mar-2024

Summary

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Official Symbol
CD302provided by HGNC
Official Full Name
CD302 moleculeprovided by HGNC
Primary source
HGNC:HGNC:30843
See related
Ensembl:ENSG00000241399 MIM:612246; AllianceGenome:HGNC:30843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCL1; DCL-1; BIMLEC; CLEC13A
Summary
CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in liver (RPKM 51.3), lung (RPKM 34.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD302 in Genome Data Viewer
Location:
2q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159768628..159798208, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160225996..160255550, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160654719, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene RPS3A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16696 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:160911725-160912406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. Reinecke B, et al. J Virol, 2022 Apr 13. PMID 35297672, Free PMC Article
  2. Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses. Watanabe R, et al. J Virol, 2022 Apr 13. PMID 35297671, Free PMC Article
  3. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. Lo TH, et al. J Immunol, 2016 Aug 1. PMID 27316686
  4. Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level. Yang S, et al. Biochemistry, 2009 May 19. PMID 19317456
  5. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. Kato M, et al. J Biol Chem, 2003 Sep 5. PMID 12824192

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.
    Title: The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.
  2. Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses.
    Title: Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses.
  3. DLC1 equilibrium unfolding is characterized at the amino acid level.
    Title: Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.
  4. These studies confirm a functional role for CD302 in myeloid dendritic cells migration.
    Title: Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  6. hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration
    Title: The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration.
  7. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1
    Title: Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD302 (DCL1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough LY75-CD302

Readthrough gene: LY75-CD302, Included gene: LY75

Homology

Clone Names

  • FLJ43091, KIAA0022, MGC22301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phagocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in microvillus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD302 antigen
Names
C-type lectin domain family 13, member A
DEC205-associated C-type lectin 1
type I transmembrane C-type lectin receptor DCL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198763.2 → NP_001185692.1  CD302 antigen isoform 2 precursor

    See identical proteins and their annotated locations for NP_001185692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, AK304422, CB240843
    Consensus CDS
    CCDS56139.1
    UniProtKB/Swiss-Prot
    Q8IX05
    Related
    ENSP00000394301.2, ENST00000429078.6
    Conserved Domains (1) summary
    smart00034
    Location:24 → 98
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  2. NM_001198764.2 → NP_001185693.1  CD302 antigen isoform 3 precursor

    See identical proteins and their annotated locations for NP_001185693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, CB240843, DB460994
    Consensus CDS
    CCDS74595.1
    UniProtKB/TrEMBL
    A0A087WT00
    Related
    ENSP00000451446.2, ENST00000553424.5
    Conserved Domains (1) summary
    smart00034
    Location:25 → 117
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  3. NM_014880.5 → NP_055695.2  CD302 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_055695.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009961, AK291279, AY314007, CB240843
    Consensus CDS
    CCDS33308.1
    UniProtKB/Swiss-Prot
    A8K5G4, B4E2T9, Q15009, Q8IX05
    Related
    ENSP00000259053.4, ENST00000259053.6
    Conserved Domains (1) summary
    smart00034
    Location:24 → 154
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    159768628..159798208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    160225996..160255550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IX05.1 GenPept UniProtKB/Swiss-Prot:Q8IX05

Gene LinkOut

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