Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Ubiquitin domain
- Ubiquitin-like domain
- Peptidase C16, coronavirus
- Ubiquitin conserved site
- Ubiquitin-like domain superfamily
- Papain-like viral protease, palm and finger domains, coronavirus
- Papain-like protease, thumb domain superfamily, coronavirus
- NSP3, second ubiquitin-like (Ubl) domain, coronavirus
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
ORF1ab protein and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-126024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ORF1ab protein
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.05 KDa
Source organism: Human betacoronavirus 2c Jordan-N3/2012
Expression system: Escherichia coli
UniProt:
Sequence domains: Coronavirus papain-like peptidase
Structure domains:
Length: 324 amino acids
Theoretical weight: 36.05 KDa
Source organism: Human betacoronavirus 2c Jordan-N3/2012
Expression system: Escherichia coli
UniProt:
- Canonical:
M4STU1 (Residues: 1480-1803; Coverage: 5%)
Sequence domains: Coronavirus papain-like peptidase
Structure domains:
Ubiquitin
Molecule details ›
Chain: B
Length: 75 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 75 amino acids
Theoretical weight: 8.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P62987 (Residues: 1-75; Coverage: 59%)
Sequence domains: Ubiquitin family
