5jw4

X-ray diffraction
3.7Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-212350 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (7 distinct):
Hemagglutinin Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 321 amino acids
Theoretical weight: 36.29 KDa
Source organism: Influenza A virus (A/Vietnam/1194/2004(H5N1))
Expression system: Gallus gallus
UniProt:
  • Canonical: Q6DQ34 (Residues: 17-337; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 162 amino acids
Theoretical weight: 18.68 KDa
Source organism: Influenza A virus (A/Vietnam/1194/2004(H5N1))
Expression system: Gallus gallus
UniProt:
  • Canonical: Q6DQ18 (Residues: 339-500; Coverage: 29%)
Gene name: HA
Structure domains: Hemagglutinin Ectodomain; Chain B
MEDI8852 heavy chain Chains: M, O, S, U, W
Molecule details ›
Chains: M, O, S, U, W
Length: 227 amino acids
Theoretical weight: 24.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
MEDI8852 light chain Chains: N, P, T, V, X
Molecule details ›
Chains: N, P, T, V, X
Length: 206 amino acids
Theoretical weight: 22.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
MEDI8852 heavy chain Chain: Q
Molecule details ›
Chain: Q
Length: 231 amino acids
Theoretical weight: 24.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
MEDI8852 light chain Chain: R
Molecule details ›
Chain: R
Length: 210 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 151.26Å b: 386.36Å c: 165.86Å
α: 90° β: 90.44° γ: 90°
R-values:
R R work R free
0.274 0.274 0.285
Expression systems:
  • Gallus gallus
  • Homo sapiens