Abstract
We analyzed 42 hepatocellular carcinomas (HCC) (38 patients) for mutations in the DNA mismatch repair gene hMSH2 and the p53 tumor suppressor gene, a possible upregulater of hMSH2. Mutations of the hMSH2 or p53 gene were detected in 13 patients (34%). There were no patients who possessed mutations in both genes. There was a significant correlation between mutation of either gene and pathological indicators of malignancy. The survival rate of patients with hMSH2 or p53 gene mutation-positive tumors was much poorer than that with hMSH2 and p53 gene mutation-negative tumors (p=0.0012). Our results suggest that mutations in the p53 or hMSH2 gene may closely correlate with the survival of hepatocellular carcinoma patients.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Carcinoma, Hepatocellular / diagnosis
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Carcinoma, Hepatocellular / genetics*
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Carcinoma, Hepatocellular / mortality
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DNA Repair / genetics
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DNA, Neoplasm / analysis
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DNA-Binding Proteins*
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Genetic Markers
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Humans
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Liver Neoplasms / diagnosis
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Liver Neoplasms / genetics*
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Liver Neoplasms / mortality
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Microsatellite Repeats / genetics
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MutS Homolog 2 Protein
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Mutation*
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Prognosis
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Proto-Oncogene Proteins / genetics*
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Recurrence
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Survival Rate
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Tumor Suppressor Protein p53 / genetics*
Substances
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DNA, Neoplasm
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DNA-Binding Proteins
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Genetic Markers
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Proto-Oncogene Proteins
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Tumor Suppressor Protein p53
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MSH2 protein, human
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MutS Homolog 2 Protein