Abstract
The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Adolescent
-
Artificial Gene Fusion
-
Child
-
Child, Preschool
-
Chromosomes, Human, Pair 12
-
Chromosomes, Human, Pair 21
-
Core Binding Factor Alpha 2 Subunit
-
Hematopoiesis / genetics
-
Humans
-
Leukemia / genetics*
-
Leukemia, Myeloid, Acute / genetics
-
Neoplasm Proteins / genetics*
-
Oncogene Proteins, Fusion*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
-
Proto-Oncogenes
-
Translocation, Genetic*
Substances
-
Core Binding Factor Alpha 2 Subunit
-
Neoplasm Proteins
-
Oncogene Proteins, Fusion
-
TEL-AML1 fusion protein