Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505)

M Koike; T Tasaka; S Spira; N Tsuruoka; H P Koeffler

doi:10.1016/s0145-2126(98)00159-3

Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505)

Leuk Res. 1999 Mar;23(3):307-10. doi: 10.1016/s0145-2126(98)00159-3.

Authors

M Koike¹, T Tasaka, S Spira, N Tsuruoka, H P Koeffler

Affiliation

¹ Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA.

PMID: 10071086
DOI: 10.1016/s0145-2126(98)00159-3

Abstract

Loss of a whole chromosome 7(-7) or a deletion of the long arm of chromosome 7 del(7q) occurs frequently in many types of primary cancers including cases of acute myelogenous leukemia (AML). We analyzed for loss of heterozygosity (LOH) of chromosome arm 7q in 26 AML cases using a set of 15 microsatellite markers in order to begin to determine the location of putative tumor suppressor genes (TSG) important to this disease. Seven samples (27%) showed LOH at one or more loci on chromosome 7q. We identified the smallest commonly deleted regions to be at 7q31.1 (D7S486) and 7q33-34 (D7S498, D7S505) suggesting that alterations of a TSG in each region have an important role in de novo AML.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Alleles
Chromosomes, Human, Pair 7*
Humans
Leukemia, Myeloid, Acute / genetics*
Loss of Heterozygosity*

Grants and funding

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