Abstract
A molecular mechanism has been discovered that helps explain the formation of foam cells, which are components of atherosclerotic plaque. It involves the stimulation by oxidized low-density lipoprotein of its own uptake into macrophages through activation of the peroxisome proliferator-activated receptor gamma.
MeSH terms
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Arteriosclerosis / etiology*
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Arteriosclerosis / metabolism
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Humans
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Lipoproteins, LDL / metabolism
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Lipoproteins, LDL / pharmacology*
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Macrophages / metabolism
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Response Elements
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Lipoproteins, LDL
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors
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oxidized low density lipoprotein