The role of oxidized low-density lipoprotein in the activation of peroxisome proliferator-activated receptor gamma: implications for atherosclerosis

Nutr Rev. 1999 Mar;57(3):88-91. doi: 10.1111/j.1753-4887.1999.tb06929.x.

Abstract

A molecular mechanism has been discovered that helps explain the formation of foam cells, which are components of atherosclerotic plaque. It involves the stimulation by oxidized low-density lipoprotein of its own uptake into macrophages through activation of the peroxisome proliferator-activated receptor gamma.

Publication types

  • Review

MeSH terms

  • Arteriosclerosis / etiology*
  • Arteriosclerosis / metabolism
  • Humans
  • Lipoproteins, LDL / metabolism
  • Lipoproteins, LDL / pharmacology*
  • Macrophages / metabolism
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Response Elements
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Lipoproteins, LDL
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • oxidized low density lipoprotein