Abstract
We report a case of acute myeloid leukemia FAB-type 2 with a translocation t(15;17)(q22;q12) On the basis of the cytological findings, a translocation t(8;21)(q22;q22) was suspected. FISH analyses using specific probes for t(15;17) and t(8;21) detected both PML/RARalpha and AML1/ETO rearrangements in a few percentage of cells. This case demonstrates the complexities that may occur between cytology and cytogenetic findings and the usefulness of FISH methods to detect an AML1/ETO rearrangement only suspected by cytological examination of bone marrow smears.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Bone Marrow / pathology
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Chromosomes, Human, Pair 15*
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Chromosomes, Human, Pair 17*
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Core Binding Factor Alpha 2 Subunit
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Female
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Gene Rearrangement
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Humans
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In Situ Hybridization, Fluorescence
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / pathology
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Neoplasm Proteins / genetics*
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Oncogene Proteins, Fusion / genetics*
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RUNX1 Translocation Partner 1 Protein
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Receptors, Retinoic Acid / genetics*
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Recombinant Fusion Proteins / genetics
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Retinoic Acid Receptor alpha
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Transcription Factors / genetics*
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Translocation, Genetic*
Substances
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AML1-ETO fusion protein, human
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Core Binding Factor Alpha 2 Subunit
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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RARA protein, human
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RUNX1 Translocation Partner 1 Protein
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Receptors, Retinoic Acid
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Recombinant Fusion Proteins
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Retinoic Acid Receptor alpha
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Transcription Factors
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promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein