Four cases of follicular lymphoma with t(14;18)(q32;q21) and t(3;4)(q27;p13) with LAZ3 (BCL6) rearrangement

Cancer Genet Cytogenet. 1999 Jun;111(2):157-60. doi: 10.1016/s0165-4608(98)00239-8.

Abstract

We report four cases of follicular lymphoma with both t(14;18)(q32;q21) and the newly characterized t(3;4)(q27;p13). Molecular investigation confirmed LAZ3 (BCL6) rearrangement for all patients. The 3q27 aberrations have been rarely described in low-grade lymphomas and may represent secondary events whose implication remains to be elucidated.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Blotting, Southern
  • Chromosomes, Human*
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 18
  • Chromosomes, Human, Pair 3
  • Chromosomes, Human, Pair 4
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Rearrangement, B-Lymphocyte
  • Humans
  • Karyotyping
  • Lymphoma, Follicular / drug therapy
  • Lymphoma, Follicular / genetics*
  • Lymphoma, Non-Hodgkin
  • Middle Aged
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-6
  • Transcription Factors / genetics*
  • Translocation, Genetic*
  • Zinc Fingers / genetics

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-6
  • Transcription Factors