Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (-), CD14 (-), and CD33(-)

Ann Hematol. 1999 May;78(5):237-40. doi: 10.1007/s002770050508.

Abstract

Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (-), CD33(-), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibiotics, Antineoplastic / therapeutic use
  • Antigens, CD / blood
  • Antigens, Differentiation, Myelomonocytic / blood
  • Antimetabolites, Antineoplastic / therapeutic use
  • Bone Marrow Cells / classification
  • CD13 Antigens / blood
  • Cell Adhesion Molecules / blood
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Cytarabine / therapeutic use
  • Female
  • Flow Cytometry
  • Humans
  • Idarubicin / therapeutic use
  • Immunophenotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Lipopolysaccharide Receptors / blood
  • Male
  • Membrane Glycoproteins / blood
  • Peroxidase / blood
  • Phenotype
  • Sialic Acid Binding Ig-like Lectin 3
  • Translocation, Genetic*

Substances

  • Antibiotics, Antineoplastic
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Antimetabolites, Antineoplastic
  • CD33 protein, human
  • Cell Adhesion Molecules
  • Lipopolysaccharide Receptors
  • Membrane Glycoproteins
  • Sialic Acid Binding Ig-like Lectin 3
  • Cytarabine
  • Peroxidase
  • CD13 Antigens
  • Idarubicin