Abstract
Coronin was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. The diversity of function in this family of actin-associated proteins is just beginning to be explored.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Actins / metabolism
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Amino Acid Sequence
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Animals
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Biopolymers
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Dictyostelium / genetics
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Dictyostelium / metabolism
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Endocytosis
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Forecasting
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Fungal Proteins / genetics
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Fungal Proteins / isolation & purification
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Fungal Proteins / physiology
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Helminth Proteins / chemistry
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Helminth Proteins / genetics
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Humans
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Mammals / metabolism
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Microfilament Proteins* / genetics
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Microfilament Proteins* / isolation & purification
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Microfilament Proteins* / physiology
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Microfilament Proteins* / ultrastructure
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Microtubules / metabolism
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Molecular Sequence Data
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Phosphorylation
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Protein Processing, Post-Translational
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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Actins
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Biopolymers
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Fungal Proteins
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Helminth Proteins
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Microfilament Proteins
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coronin proteins