Abstract
We report the case of a 43-year-old schizophrenic who sustained, after 12 days of treatment including olanzapine (20 mg.day-1), carbamazepine, levomepromazine and alprazolan, a severe shock with bradycardia (HR: 40 b.min-1), circulatory collapse (SAP: 60 mmHg), hypothermia (T: 27 degrees C), coma and disseminated intravascular coagulation. A significant improvement was obtained with high doses of intravenous glucagon, whereas the normalization of central temperature, atropine, adrenaline and volume loading had been inefficient. Olanzapine, alone of associated with other psychotropics, could cause severe circulatory collapse with hypothermia and coma responding to a treatment including glucagon.
MeSH terms
-
Adult
-
Alprazolam / therapeutic use
-
Antipsychotic Agents / adverse effects
-
Antipsychotic Agents / therapeutic use*
-
Benzodiazepines
-
Bradycardia / chemically induced
-
Carbamazepine / therapeutic use
-
Disseminated Intravascular Coagulation / chemically induced*
-
Disseminated Intravascular Coagulation / drug therapy
-
Drug Therapy, Combination
-
Gastrointestinal Agents / administration & dosage
-
Gastrointestinal Agents / therapeutic use*
-
Glucagon / administration & dosage
-
Glucagon / therapeutic use*
-
Humans
-
Hypothermia / chemically induced
-
Infusions, Intravenous
-
Male
-
Methotrimeprazine / therapeutic use
-
Olanzapine
-
Pirenzepine / adverse effects
-
Pirenzepine / analogs & derivatives*
-
Schizophrenia / drug therapy*
-
Shock / chemically induced
Substances
-
Antipsychotic Agents
-
Gastrointestinal Agents
-
Benzodiazepines
-
Carbamazepine
-
Pirenzepine
-
Glucagon
-
Methotrimeprazine
-
Olanzapine
-
Alprazolam