Abstract
Among non-smokers, the factors resulting in lung carcinogenesis are poorly understood. We conducted a hospital-based case-control analysis of 294 Chinese women, of whom 217 were non-smokers, to evaluate the role of polymorphic N-acetyltransferase (NAT2) as a susceptibility factor for the disease. The proportion of slow acetylator genotypes among non-smoking cases (n = 92) and controls (n = 125) was 38.0 and 24.0%, respectively [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.1-3.7]. No effect of NAT2 genotype was seen among smokers. Among non-smokers, the effect was marked for adenocarcinomas (OR 2.1, 95% CI 1.1-4.0). As NAT2 activity is known to modify risk of arylamine-induced carcinogenesis, our results suggest that exposure to arylamines in the environment may play a role in risk of lung cancer among non-smokers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation
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Adenocarcinoma / enzymology
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Adenocarcinoma / epidemiology*
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Adenocarcinoma / ethnology
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Adenocarcinoma / genetics
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Aged
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Amines / adverse effects
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Arylamine N-Acetyltransferase / genetics*
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Carcinoma, Non-Small-Cell Lung / enzymology
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Carcinoma, Non-Small-Cell Lung / epidemiology
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Carcinoma, Non-Small-Cell Lung / ethnology
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Small Cell / enzymology
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Carcinoma, Small Cell / epidemiology
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Carcinoma, Small Cell / ethnology
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Carcinoma, Small Cell / genetics
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Case-Control Studies
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China / ethnology
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Cooking
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Environmental Exposure
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Genotype
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Heterocyclic Compounds / adverse effects
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Humans
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Lung Neoplasms / enzymology
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Lung Neoplasms / epidemiology*
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Lung Neoplasms / ethnology
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Lung Neoplasms / genetics
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Middle Aged
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Odds Ratio
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Polymorphism, Genetic
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Singapore / epidemiology
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Smoking / epidemiology
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Smoking Cessation / statistics & numerical data
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Tobacco Smoke Pollution / statistics & numerical data
Substances
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Amines
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Heterocyclic Compounds
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Tobacco Smoke Pollution
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Arylamine N-Acetyltransferase
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NAT2 protein, human