Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

D G Bebb; Z Yu; J Chen; M Telatar; K Gelmon; N Phillips; R A Gatti; B W Glickman

doi:10.1038/sj.bjc.6690630

Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

Br J Cancer. 1999 Aug;80(12):1979-81. doi: 10.1038/sj.bjc.6690630.

Authors

D G Bebb¹, Z Yu, J Chen, M Telatar, K Gelmon, N Phillips, R A Gatti, B W Glickman

Affiliation

¹ Centre for Environmental Health, Department of Biology, University of Victoria, Canada.

Abstract

Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found.

MeSH terms

Adult
Age of Onset
Aged
Ataxia Telangiectasia / genetics
Ataxia Telangiectasia Mutated Proteins
Breast Neoplasms / blood
Breast Neoplasms / genetics*
Cell Cycle Proteins
DNA-Binding Proteins
Female
Genetic Carrier Screening*
Humans
Middle Aged
Mutation*
Polymerase Chain Reaction
Protein Serine-Threonine Kinases*
Proteins / genetics*
RNA / blood
Sensitivity and Specificity
Tumor Suppressor Proteins

Substances

Cell Cycle Proteins
DNA-Binding Proteins
Proteins
Tumor Suppressor Proteins
RNA
ATM protein, human
Ataxia Telangiectasia Mutated Proteins
Protein Serine-Threonine Kinases