Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials

Am J Hum Genet. 1999 Oct;65(4):1148-60. doi: 10.1086/302571.

Abstract

The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / genetics
  • Alcoholism / diagnosis
  • Alcoholism / enzymology
  • Alcoholism / genetics*
  • Alcoholism / physiopathology*
  • Chromosome Mapping / methods*
  • Chromosome Mapping / statistics & numerical data
  • Chromosomes, Human, Pair 4 / genetics
  • Event-Related Potentials, P300 / genetics*
  • Event-Related Potentials, P300 / physiology*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genome, Human
  • Humans
  • Likelihood Functions
  • Lod Score
  • Male
  • Pedigree
  • Quantitative Trait, Heritable*

Substances

  • Alcohol Dehydrogenase