Abstract
The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alleles
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Androgens / blood
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Breast Neoplasms / blood
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Breast Neoplasms / enzymology
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Breast Neoplasms / genetics
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Breast Neoplasms, Male / blood
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Breast Neoplasms, Male / enzymology*
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Breast Neoplasms, Male / genetics*
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Case-Control Studies
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Estrogens / blood
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Female
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Genotype
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Humans
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Male
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Middle Aged
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Polymorphism, Genetic*
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Steroid 17-alpha-Hydroxylase / genetics*
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Steroid 17-alpha-Hydroxylase / metabolism
Substances
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Androgens
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Estrogens
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Steroid 17-alpha-Hydroxylase