A polymorphism in the CYP17 gene is associated with male breast cancer

I E Young; K M Kurian; C Annink; I H Kunkler; V A Anderson; B B Cohen; M L Hooper; A H Wyllie; C M Steel

doi:10.1038/sj.bjc.6690663

A polymorphism in the CYP17 gene is associated with male breast cancer

Br J Cancer. 1999 Sep;81(1):141-3. doi: 10.1038/sj.bjc.6690663.

Authors

I E Young¹, K M Kurian, C Annink, I H Kunkler, V A Anderson, B B Cohen, M L Hooper, A H Wyllie, C M Steel

Affiliation

¹ University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK.

Abstract

The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Alleles
Androgens / blood
Breast Neoplasms / blood
Breast Neoplasms / enzymology
Breast Neoplasms / genetics
Breast Neoplasms, Male / blood
Breast Neoplasms, Male / enzymology*
Breast Neoplasms, Male / genetics*
Case-Control Studies
Estrogens / blood
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic*
Steroid 17-alpha-Hydroxylase / genetics*
Steroid 17-alpha-Hydroxylase / metabolism

Substances

Androgens
Estrogens
Steroid 17-alpha-Hydroxylase