Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement

F Marco; E Bureo; M D Delgado; C Richard; M A Cuadrado; J A Pérez Retortillo; M Recio; A Zubizarreta

doi:10.1016/s0165-4608(99)00041-2

Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement

Cancer Genet Cytogenet. 1999 Oct 1;114(1):68-70. doi: 10.1016/s0165-4608(99)00041-2.

Authors

F Marco¹, E Bureo, M D Delgado, C Richard, M A Cuadrado, J A Pérez Retortillo, M Recio, A Zubizarreta

Affiliation

¹ Servicio de Hematología del Hospital Universitario Marqués de Valdecilla, Santander, Spain.

PMID: 10526538
DOI: 10.1016/s0165-4608(99)00041-2

Abstract

Molecular rearrangements of the MLL gene at the 11q23 region have been identified in most cases of infant leukemia, regardless of the phenotype. We present a case of acute myeloid leukemia which coexpressed myeloid and lymphoid markers in a 12-month-old girl. Karyotype analysis revealed the presence of a thus far unreported translocation t(10;11)(p13;p15). Although no 11q23 abnormalities were cytogenetically detectable, an MLL gene molecular rearrangement was found.

Publication types

Case Reports

MeSH terms

Acute Disease
Chromosomes, Human, Pair 10*
Chromosomes, Human, Pair 11*
DNA-Binding Proteins / genetics*
Female
Gene Rearrangement*
Histone-Lysine N-Methyltransferase
Humans
Infant
Leukemia, Myeloid / genetics*
Myeloid-Lymphoid Leukemia Protein
Proto-Oncogenes*
Transcription Factors*
Translocation, Genetic*

Substances

DNA-Binding Proteins
KMT2A protein, human
Transcription Factors
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase