Abstract
A young man with acute lymphoblastic leukemia was treated with vincristine sulfate, prednisone, and intrathecally injected methotrexate sodium for central nervous system involvement. A good remission was induced, but three months later he had hepatosplenomegaly, an enlarging mediastinal mass, and progressive anemia. Histiocytic medullary reticulosis was confirmed by a bone marrow biopsy specimen. The patient died of respiratory failure because of infiltration of the lungs by malignant histiocytes.
MeSH terms
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Acute Disease
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Adult
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Anemia / diagnosis
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Autopsy
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Bone Marrow / pathology
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Erythrocytes
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Hepatomegaly / diagnosis
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Humans
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Leukemia, Lymphoid / drug therapy
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Leukemia, Lymphoid / pathology*
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Lymph Nodes / pathology
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Lymphatic Diseases / pathology*
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Male
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Methotrexate / therapeutic use
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Phagocytosis
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Prednisone / therapeutic use
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Remission, Spontaneous
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Respiratory Insufficiency / pathology
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Sodium / therapeutic use
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Splenomegaly / diagnosis
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Sulfates / therapeutic use
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Vincristine / therapeutic use
Substances
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Sulfates
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Vincristine
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Sodium
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Prednisone
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Methotrexate