Abstract
Expression of CD30 is a distinct feature of B- or T-cell activation, found in Hodgkin's disease, large cell anaplastic lymphoma, lymphomatoid papulosis, as well as in certain viral infections such as human T-lymphotropic virus type I, HIV, hepatitis B and C virus, and Epstein-Barr virus. Here, we report highly proliferative CD30-positive cutaneous infiltrates in 3 patients with Milkers's nodules, adding parapoxvirus infection to the spectrum of CD30-positive benign lympho-proliferations.
MeSH terms
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Adult
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Aged
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Animals
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B-Lymphocytes / metabolism
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B-Lymphocytes / pathology
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Cattle
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Female
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics
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Humans
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Ki-1 Antigen / biosynthesis*
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Ki-1 Antigen / genetics
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / pathology
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Lymphoproliferative Disorders / virology
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Male
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Middle Aged
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Parapoxvirus / pathogenicity*
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Parapoxvirus / ultrastructure
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Poxviridae Infections / genetics
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Poxviridae Infections / metabolism*
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Poxviridae Infections / pathology
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Receptors, Antigen, T-Cell / analysis
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Skin / pathology
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Skin / virology*
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Skin Diseases, Viral / genetics
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Skin Diseases, Viral / metabolism*
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Skin Diseases, Viral / pathology
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T-Lymphocytes / metabolism
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T-Lymphocytes / pathology
Substances
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Ki-1 Antigen
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Receptors, Antigen, T-Cell