Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

R A Pereira; M M Simon; A Simmons

doi:10.1128/jvi.74.2.1029-1032.2000

Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

J Virol. 2000 Jan;74(2):1029-32. doi: 10.1128/jvi.74.2.1029-1032.2000.

Authors

R A Pereira¹, M M Simon, A Simmons

Affiliation

¹ Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia. Rosemary.Pereira@imvs.sa.gov.au

Abstract

Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / physiology*
Disease Models, Animal
Ganglia, Spinal / immunology
Ganglia, Spinal / pathology
Ganglia, Spinal / virology
Granzymes
Herpes Simplex / immunology*
Herpes Simplex / pathology
Herpes Simplex / virology
Herpesvirus 1, Human / immunology
Herpesvirus 1, Human / physiology
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Peripheral Nervous System / virology*
Serine Endopeptidases / genetics
Serine Endopeptidases / physiology*
T-Lymphocytes, Cytotoxic / immunology*
Viral Load

Substances

Antiviral Agents
Granzymes
Serine Endopeptidases
GZMA protein, human