Abstract
OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40. After infection with LCMV and influenza virus, OX40-/- mice retain primary and memory cytotoxic T cell responses with normal expansion and decline of specific CTL. In contrast, CD4+ T cell proliferation and the number of IFN-gamma-producing CD4+ T cells were reduced in OX40-/- mice. Moreover, the number of CD4+ T cells infiltrating the lungs of influenza virus-infected OX40-/- mice was reduced. These results define a unique role of OX40 in the generation of optimal CD4+ T cell responses in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / immunology
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B-Lymphocytes / immunology*
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B-Lymphocytes / virology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / virology
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Cell Division
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Cell Line
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Dogs
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Female
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Humans
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Influenza A virus / immunology
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Lymphocytic choriomeningitis virus / immunology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Receptors, OX40
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / immunology*
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Cytotoxic / virology
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Helper-Inducer / virology
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / genetics
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology*
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Vesicular stomatitis Indiana virus / immunology
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Virus Diseases / immunology*
Substances
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Antibodies, Viral
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Receptors, OX40
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Receptors, Tumor Necrosis Factor
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TNFRSF4 protein, human
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Tnfrsf4 protein, mouse
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Tumor Necrosis Factor Receptor Superfamily, Member 7