Abstract
We report the unusual occurrence of Kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi' sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi's sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi's sarcoma in the presence of HHV8 infection.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / blood
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Antigens, Viral / immunology
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DNA Primers / chemistry
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DNA, Neoplasm / analysis
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DNA, Viral / genetics
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HIV Seronegativity
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Herpesvirus 8, Human / genetics
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Herpesvirus 8, Human / immunology
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Herpesvirus 8, Human / isolation & purification
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Humans
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Interleukin-6 / analysis
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Male
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Mesothelioma / complications*
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Mesothelioma / immunology
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Mesothelioma / pathology
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Middle Aged
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Neoplasms, Second Primary / etiology*
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Neoplasms, Second Primary / immunology
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Neoplasms, Second Primary / pathology
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Neoplasms, Second Primary / virology
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Platelet-Derived Growth Factor / analysis
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Pleural Neoplasms / complications*
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Pleural Neoplasms / immunology
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Pleural Neoplasms / pathology
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Polymerase Chain Reaction
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Sarcoma, Kaposi / etiology*
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Sarcoma, Kaposi / immunology
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Sarcoma, Kaposi / pathology
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Sarcoma, Kaposi / virology
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Skin Neoplasms / etiology*
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Skin Neoplasms / immunology
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Skin Neoplasms / pathology
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Skin Neoplasms / virology
Substances
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Antibodies, Viral
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Antigens, Viral
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DNA Primers
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DNA, Neoplasm
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DNA, Viral
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Interleukin-6
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Platelet-Derived Growth Factor