Analysis of HLA-DRB1 alleles in Japanese patients with chronic myelogenous leukemia

Am J Hematol. 2000 Feb;63(2):99-101. doi: 10.1002/(sici)1096-8652(200002)63:2<99::aid-ajh8>3.0.co;2-#.

Abstract

To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Fusion Proteins, bcr-abl / genetics
  • Gene Frequency / genetics*
  • Genotype
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Japan
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
  • Polymorphism, Restriction Fragment Length
  • Reference Values
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Fusion Proteins, bcr-abl