A family of chromatin remodeling factors related to Williams syndrome transcription factor

Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1038-43. doi: 10.1073/pnas.97.3.1038.

Abstract

Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / isolation & purification*
  • Adenosine Triphosphatases / physiology
  • Amino Acid Sequence
  • Animals
  • Chromatin / metabolism*
  • Chromatin / ultrastructure
  • Chromosomal Proteins, Non-Histone
  • DNA Helicases
  • DNA-Binding Proteins / metabolism
  • Deoxyribonuclease I / metabolism
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics
  • Fungal Proteins / physiology
  • HeLa Cells
  • Humans
  • Macromolecular Substances
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / isolation & purification
  • Neoplasm Proteins / physiology
  • Nuclear Proteins*
  • Nucleosomes / metabolism
  • Protein Structure, Tertiary
  • RNA-Binding Proteins*
  • Ribonucleoprotein, U1 Small Nuclear / physiology
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / isolation & purification*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology
  • Williams Syndrome / genetics*

Substances

  • Acf protein, Drosophila
  • BAZ1A protein, human
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Fungal Proteins
  • ISWI protein
  • Macromolecular Substances
  • Neoplasm Proteins
  • Nuclear Proteins
  • Nucleosomes
  • RNA-Binding Proteins
  • Ribonucleoprotein, U1 Small Nuclear
  • SMARCA1 protein, human
  • SMARCA2 protein, human
  • Transcription Factors
  • snf protein, Drosophila
  • Deoxyribonuclease I
  • Adenosine Triphosphatases
  • SMARCA4 protein, human
  • DNA Helicases

Associated data

  • GENBANK/AF221130