alpha(2)-Adrenergic receptors have been thought to play a crucial role in the etiology or treatment of panic disorders. Polymorphism(s) in the promoter region of the alpha(2) receptor may affect gene expression and be associated with panic disorders. We studied the polymorphism of the alpha(2A) receptor gene at position -1291 reported by Lario et al. (Lario, S., Calls, J., Cases, A., Oriola, J., Torras, A., Rivera, F., 1997. Short repeat on DNA marker at candidate locus. MspI identifies a biallelic polymorphism in the promoter region of the alpha(2A)-adrenergic receptor gene. Clinical Genetics 51, 129-130.) in 114 healthy control subjects and 55 patients with panic disorders. There was no statistically significant difference between controls and patients in either genotype or allele frequency. Our results suggest there is no association between this polymorphism in the promoter region of the alpha(2A) receptor gene and panic disorders.