EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface

Cancer Res. 2000 Feb 15;60(4):888-91.

Abstract

Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at the tumor cell surface. Complex formation was demonstrated by phage display, affinity chromatography, and immunocytochemistry. Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in modifying the tumor cell pericellular matrix to promote invasion.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antigens, CD*
  • Antigens, Neoplasm / metabolism*
  • Base Sequence
  • Basigin
  • Collagenases / metabolism*
  • Humans
  • Matrix Metalloproteinase 1 / biosynthesis*
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • Molecular Weight

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • BSG protein, human
  • Membrane Glycoproteins
  • Basigin
  • Collagenases
  • Matrix Metalloproteinase 1