Abstract
The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blotting, Western
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Brain / metabolism*
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Cell Line
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Hypoxia-Ischemia, Brain / metabolism*
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Immunohistochemistry
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Microglia / metabolism*
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Proto-Oncogene Proteins / biosynthesis*
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Rats
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Rats, Wistar
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Time Factors
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Trans-Activators / biosynthesis*
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Up-Regulation
Substances
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Proto-Oncogene Proteins
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Trans-Activators
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proto-oncogene protein Spi-1