Abstract
Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles*
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Base Sequence
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Child
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Child, Preschool
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DNA Primers
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Female
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Hepatoblastoma / genetics*
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Humans
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Infant
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Infant, Newborn
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Insulin-Like Growth Factor II / genetics*
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Liver Neoplasms / genetics*
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Male
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Muscle Proteins / genetics*
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RNA, Long Noncoding
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RNA, Untranslated*
Substances
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DNA Primers
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H19 long non-coding RNA
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Muscle Proteins
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RNA, Long Noncoding
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RNA, Untranslated
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Insulin-Like Growth Factor II