Abstract
The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through which they act.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apolipoproteins E / deficiency*
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Apolipoproteins E / genetics
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Apolipoproteins E / physiology
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Arteriosclerosis / etiology*
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Cholesterol, Dietary / administration & dosage
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Cholesterol, Dietary / pharmacology*
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Dietary Fats / administration & dosage
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Dietary Fats / pharmacology*
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Humans
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Lipoproteins / blood
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Mice
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Mice, Knockout
Substances
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Apolipoproteins E
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Cholesterol, Dietary
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Dietary Fats
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Lipoproteins