A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson's disease

H Morino; T Kawarai; Y Izumi; T Kazuta; M Oda; O Komure; F Udaka; M Kameyama; S Nakamura; H Kawakami

A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson's disease

Ann Neurol. 2000 Apr;47(4):528-31.

Authors

H Morino¹, T Kawarai, Y Izumi, T Kazuta, M Oda, O Komure, F Udaka, M Kameyama, S Nakamura, H Kawakami

Affiliation

¹ Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.

PMID: 10762168

Abstract

We identified two polymorphisms out of all coding regions of the dopamine transporter gene. One existed in exon 9 (1215A/G) and another in exon 15 (1898T/C). The 1215G was significantly less frequent among patients with Parkinson's disease than the controls. Although the polymorphism caused no amino acid substitution, we concluded that it was associated with decreasing the susceptibility to Parkinson's disease through mechanisms other than the protein function of dopamine transporter.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carrier Proteins / genetics*
DNA Mutational Analysis
Dopamine Plasma Membrane Transport Proteins
Electrophoresis, Capillary
Exons / genetics
Female
Humans
Linkage Disequilibrium
Male
Membrane Glycoproteins*
Membrane Transport Proteins*
Middle Aged
Nerve Tissue Proteins*
Parkinson Disease / genetics*
Polymorphism, Single Nucleotide*
Polymorphism, Single-Stranded Conformational

Substances

Carrier Proteins
Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins