Abstract
In the present study, mutations or protein expression of p53, bcl-2 and bax are reported in 13 non-Hodgkin's B-cell lymphomas of the head and neck. Nine of 13 cases (69.2%) expressed p53 protein and 7 (53.8%) showed gene mutations. On comparing the results of immunostaining and SSCP analysis, there were two cases showing discrepancies between the p53 protein expression and gene mutations. Bcl-2 protein expression was observed in only two cases of follicular lymphoma. On the other hand, bax protein was detected in all 13 cases. One case with mutated bax gene showed a lower expression with a reduced frequency of bax-positive cells than the other 12. These results suggest that inactivation of p53 may be closely related to development and/or progression of these NHLs, and that bcl-2 and bax protein may not have a role.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / pathology
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Child
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Disease Progression
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Female
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Gene Expression Regulation, Neoplastic
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Gene Silencing
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Genes, p53 / genetics
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Head and Neck Neoplasms / genetics*
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Humans
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Immunoenzyme Techniques
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Lymphoma, B-Cell / genetics
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Lymphoma, B-Cell / pathology
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Lymphoma, Follicular / genetics
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Lymphoma, Follicular / pathology
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Lymphoma, Large B-Cell, Diffuse / genetics
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Non-Hodgkin / genetics*
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Lymphoma, Non-Hodgkin / pathology
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Male
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Middle Aged
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Mutation / genetics
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Polymorphism, Single-Stranded Conformational
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-bcl-2 / genetics*
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Tumor Suppressor Protein p53 / genetics*
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bcl-2-Associated X Protein
Substances
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BAX protein, human
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53
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bcl-2-Associated X Protein