Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

J Immunol. 2000 May 15;164(10):4991-5. doi: 10.4049/jimmunol.164.10.4991.

Abstract

We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Biomarkers / blood
  • Calcium Signaling / immunology
  • Chemokines / metabolism
  • Cytokines / metabolism
  • Fungi / immunology
  • Gram-Negative Bacteria / immunology
  • Gram-Positive Bacteria / immunology
  • Humans
  • Immunoglobulins / biosynthesis
  • Immunoglobulins / genetics
  • Immunoglobulins / physiology
  • Inflammation / immunology
  • Inflammation / microbiology
  • Macrophage Activation / immunology
  • Membrane Glycoproteins / blood
  • Membrane Proteins
  • Molecular Sequence Data
  • Molecular Weight
  • Monocytes / immunology*
  • Monocytes / metabolism*
  • Monocytes / microbiology
  • Multigene Family / immunology
  • Neutrophil Activation / immunology
  • Neutrophils / immunology*
  • Neutrophils / metabolism*
  • Neutrophils / microbiology
  • Phosphorylation
  • Receptors, Immunologic / biosynthesis*
  • Receptors, Immunologic / blood
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / physiology*
  • Triggering Receptor Expressed on Myeloid Cells-1
  • Tyrosine / blood
  • Up-Regulation / immunology

Substances

  • Adaptor Proteins, Signal Transducing
  • Biomarkers
  • Chemokines
  • Cytokines
  • Immunoglobulins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • TREM2 protein, human
  • TYROBP protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1
  • Tyrosine

Associated data

  • GENBANK/AF196329
  • GENBANK/AF213457