Abstract
Data obtained in experimental cutaneous melanomas have suggested that the nm23 gene may function as a metastasis suppressor gene. The nm23 level in 8 human cutaneous melanoma cell lines and 2 murine melanoma cell lines were examined. Each melanoma cell line was transplanted subcutaneously into the flank of nude mice, and the metastatic behavior was evaluated by counting lung tumor foci and by determining host survival time. It was found that expression of nm23 mRNA in human melanomas is correlated closely with reduced metastatic behavior in experimental animals and may serve as a sensitive prognostic indicator of malignancy and survival in patients with melanomas.
MeSH terms
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Animals
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Biomarkers, Tumor
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Female
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Genes, Tumor Suppressor*
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Humans
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Melanoma / genetics
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Melanoma / pathology*
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Melanoma, Experimental / genetics
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Melanoma, Experimental / pathology*
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Monomeric GTP-Binding Proteins / biosynthesis*
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Monomeric GTP-Binding Proteins / genetics
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NM23 Nucleoside Diphosphate Kinases
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Neoplasm Transplantation
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Nucleoside-Diphosphate Kinase*
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RNA, Messenger / biosynthesis
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Skin Neoplasms / genetics
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Skin Neoplasms / pathology*
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics
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Tumor Cells, Cultured
Substances
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Biomarkers, Tumor
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NM23 Nucleoside Diphosphate Kinases
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RNA, Messenger
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Transcription Factors
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NME1 protein, human
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Nme1 protein, mouse
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Nucleoside-Diphosphate Kinase
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Monomeric GTP-Binding Proteins