Association of the N-acetyltransferase I gene (NATI) with mild and severe substance abuse

Neuroreport. 2000 Apr 27;11(6):1227-30. doi: 10.1097/00001756-200004270-00017.

Abstract

We observed a significant increase in the number subjects carrying the NAT1* 10 allele of the N-acetyl transferasel (NAT1) gene in controls with a MAST-R score of > or = 4 and in subjects with drug and/or alcohol dependence (p=0.003), compared with controls with a MAST-R <4. These results suggest that alterations in the acetylation of one or more CNS compounds may be related to both mild and severe substance abuse.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alleles
  • Arylamine N-Acetyltransferase / genetics*
  • Gene Frequency
  • Genetic Linkage*
  • Genotype
  • Heterozygote
  • Homozygote
  • Humans
  • Isoenzymes / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Severity of Illness Index
  • Sex Distribution
  • Substance-Related Disorders / enzymology*
  • Substance-Related Disorders / genetics*
  • White People / genetics

Substances

  • Isoenzymes
  • Arylamine N-Acetyltransferase
  • N-acetyltransferase 1