Abstract
We observed a significant increase in the number subjects carrying the NAT1* 10 allele of the N-acetyl transferasel (NAT1) gene in controls with a MAST-R score of > or = 4 and in subjects with drug and/or alcohol dependence (p=0.003), compared with controls with a MAST-R <4. These results suggest that alterations in the acetylation of one or more CNS compounds may be related to both mild and severe substance abuse.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alleles
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Arylamine N-Acetyltransferase / genetics*
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Gene Frequency
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Genetic Linkage*
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Genotype
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Heterozygote
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Homozygote
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Humans
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Isoenzymes / genetics*
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Male
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Middle Aged
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Polymorphism, Genetic
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Severity of Illness Index
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Sex Distribution
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Substance-Related Disorders / enzymology*
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Substance-Related Disorders / genetics*
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White People / genetics
Substances
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Isoenzymes
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Arylamine N-Acetyltransferase
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N-acetyltransferase 1