Abstract
Syndecans, transmembrane proteoglycans, play an important role in cell-matrix and cell-cell interactions, as well as modulators in receptor activation. These functions are partly non-specific and related to the heparan sulfate chains attached to the ectodomain, and partly specific due to the transmembrane and cytoplasmic domains of the core protein. In hemopoietic cells syndecan-1 is expressed only in B cells at certain differentiation stages (pre-B and plasma cells). In lymphoproliferative conditions this selective expression is retained in myelomas/plasmacytomas and other lymphoplasmacytic NHL subtypes, and primary effusional lymphomas. It is probably gained in B-CLL, and lost in other NHLs of pre- or post-follicular origin. It is concluded from these empiric results that the expression of syndecan is essential for some NHLs, probably ensuring the required connections to the microenvironment. From a diagnostic point of view, syndecan-1 is a very useful phenotypic marker to indentify cells with plasmacytic differentiation. The importance of syndecan expression in CLL and Hodgkin's lymphoma still requires further studies.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
ADAM Proteins
-
ADAM12 Protein
-
Animals
-
B-Lymphocytes / cytology
-
B-Lymphocytes / metabolism
-
Biomarkers, Tumor
-
Cell Adhesion / physiology
-
Cell Communication / physiology
-
Cell Differentiation
-
Chromosomes, Human, Pair 2 / genetics
-
Cytokines / metabolism
-
Extracellular Matrix / physiology
-
Gene Expression Regulation
-
Humans
-
Interleukin-6 / pharmacology
-
Lymphoid Tissue / metabolism*
-
Lymphoma / metabolism
-
Lymphoma / pathology
-
Lymphoproliferative Disorders / metabolism
-
Lymphoproliferative Disorders / pathology
-
Macromolecular Substances
-
Membrane Glycoproteins / chemistry
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / physiology*
-
Membrane Proteins / metabolism
-
Metalloendopeptidases / metabolism
-
Neoplasm Invasiveness
-
Neoplasm Proteins / physiology
-
Plasmacytoma / metabolism
-
Plasmacytoma / pathology
-
Protein Conformation
-
Proteoglycans / chemistry
-
Proteoglycans / genetics
-
Proteoglycans / physiology*
-
Receptors, Cytokine / metabolism
-
Recombinant Fusion Proteins / physiology
-
Signal Transduction
-
Syndecan-1
-
Syndecans
-
Transfection
Substances
-
Biomarkers, Tumor
-
Cytokines
-
Interleukin-6
-
Macromolecular Substances
-
Membrane Glycoproteins
-
Membrane Proteins
-
Neoplasm Proteins
-
Proteoglycans
-
Receptors, Cytokine
-
Recombinant Fusion Proteins
-
SDC1 protein, human
-
Syndecan-1
-
Syndecans
-
ADAM Proteins
-
ADAM12 Protein
-
ADAM12 protein, human
-
Metalloendopeptidases